Paracetamol Hydrolysis question (4-aminophenol)

[Athiril]

I'm familiar with working with HCl, so thats not a bother.

As far as Sulphuric Acid goes from Auto Shops.. doubt it, most of them (we tend to only have chains around for auto markets too) sell it for 5 cents for a litre, but store policy only sells it to you with the purchase of a motorcycle battery, and 1 per customer.

I might be able to find it other places, I'll have to look. But HCl is really easy to get in any quantity, and cheap.

So the "It takes 151.17 grams of paracetamol (Tylenol) to make 109.13 grams of 4-aminophenol" applies to the free-base.. but the free-base, is it unstable for storage?

Was just looking over
http://msds.chem.ox.ac.uk/AM/4-aminophenol.html
and
http://msds.chem.ox.ac.uk/AM/4-amino...ochloride.html

Aminophenol "Stable, though may discolour in air. Incompatible with acids, chloroformates, strong oxidizing agents. "

Aminophenol HCl "Stable, but hygroscopic, air and light sensitive. Incompatible with strong oxidizing agents. "

Either case Iw ould prefer to store the HCl salt.

[john_s]

4-aminophenol is a common chemical. You could buy some. I get mine from Merck in Melbourne.

[Athiril]

How much is it?

Eg:

I already had a registered login with merck ages ago, but once I login, requests for pricing cart disappears, as does the link to make a request for pricing in all chems.

So I cant even get a quote from merck, let alone order, I presume it will be expensive.

I'd still prefer to prepare my own dry HCl salt of aminophenol.

[Alan Johnson]

Adding dilute HCl to a solution of aminophenolate produces a precipitate at around neutral pH which is probably p-aminophenol.This is probably the easiest way to make it.IMO the whole process is hazardous and non-chemists should not try it.

[john_s]

How much is it?

Eg:

I already had a registered login with merck ages ago, but once I login, requests for pricing cart disappears, as does the link to make a request for pricing in all chems.

So I cant even get a quote from merck, let alone order, I presume it will be expensive.

I'd still prefer to prepare my own dry HCl salt of aminophenol.

I just telephoned them. I don't remember the price. Whether or not it's expensive depends on quantities you can buy, quantities you need etc. I remember it being not very expensive. But I haven't used a lot of it, and it might not keep as well as some other dev agents.

[Athiril]

Adding dilute HCl to a solution of aminophenolate produces a precipitate at around neutral pH which is probably p-aminophenol.This is probably the easiest way to make it.IMO the whole process is hazardous and non-chemists should not try it.

Well I have fine enough pippettes, but a probably is kind of... well.. hmm.

I found this which may be useful to some others as well
http://books.google.com.au/books?id=...page&q&f=false