Even though I live on the west coast of Florida I would reccommend going up A1A to St Augustine, lots of nice stuff there.
You could stay on A1A and cross the river near Jacksonville by a little ferry boat and continue on to Fernadina Beach and in to GA.
If you are a little adventurous there are lots of little islands along the GA coast with some wonderful photo spots.
Then while you are in that neck of the woods you should continue north to Savannah, a wonderful place to snap away.

Then Missouri is somewhere over to the left.