I often like to print square, so I like 6x6 and consider it significantly better than 645. 645 is better than 35mm, of course, but not enough better in my opinion to justify the extra bulk of the equipment. 645 seems like a good choice if you want only one system and can't decide between medium format and 35mm.
Another attraction of 6x6, if you crop, is that you can crop from any part of the square frame, so it's a bit like getting a 645 with some rise (for horizontals) and shift (for verticals). This shot was cropped from the top of a 6x6 frame--
Aside from the fact that the proportions are a bit different from 645, the lines are straight (or as straight as they are in reality), because the camera is level, and the relationship of foreground to background is different from the image I would have gotten had I had used a 645 camera and pointed it down.