I have fairly big hands, and wide palms. Once upon a time when I was considering buying a non-silver-based camera, I went around the shops looking at their offerings. At that time the top "camera" was a sculpted thing with more buttons than you can see at the changing of the guards at Buckingham Palace...

I picked it up, and immidiately put it down again saying to the salesperson "it's amazing that such a technically advanced object can be so impossible to hold comfortably". My fingers are too long to fit around the grip, my palms too wide to fit the grip, and I would have had to amputate half of my index finger to reach the release button.

It's not just women - there are far too many cameras that simply aren't made for humans! (I'll include the Linhoif Technika III 5x7" in that - a marvel of engineering, but hopeless ergonomics for hand-held shooting. So why fit a rangefinder you can't see through with you right eye?)