As a small-handed woman, comfort is one of the reasons I love my Pentax PZ1P - it fits my hands perfectly. So does the 645N. I can reach all the controls on both without moving my hands at all, too.
Every Nikon I've used feels like a brick and my wrist hurts for days after. I always have to move my hands around to find the multiple buttons I have to push while twisting something else.
I do agree about the Hassie, but I'm keeping mine 'cause of quality - I just suffer the bulk.