Curt, theoretically yes. Since the 35mm image uses only the center of the 645 lens its taking the sharpest part of the lens. BUT....many will argue that MF lenses (most) are not built to be as sharp as some 35mm lenses because they dont need to be enlarged so much....so it kinda cancels itself out. NOW, if you find a way to mount a mamiya 7 65 or 80mm lens on a 35mm body you will have one hell of a sharp image. but the counter argument is just get a zeiss or leica 35mm lens and itll be just as sharp.