Yes, the 65 l-a is much sharper and contrastier than the 110. The 110 is really all about smoothness of bokeh and people-friendly contrast, it's not nearly as critically sharp as say the 90 or 127 lenses. In my book, the 110 is basically a wide-normal portrait lens. I have rigged it to LF camera for macro fun though, in that case the speed makes it quite enjoyable.