I recently developed 4x5s for the first time. I started off with two negatives in a tray and shuffled them. They weren't scratch free but they were pretty good over all. I still haven't printed any yet - my exposure was way off with some and the others were only decent as compositions go - but I was surprised at how easy it was over all. For my second pair, I decided to take the negatives out of the holders instead of unloading the holder and putting the negatives directly into the tray as I went. That was a mistake as my hands were still damp and they stuck together. At least that was one lesson learned.
The next round, I tried shuffling sheets to the bottom of the tray, with the emulsion up. I had fewer scratches with that batch.