I use my D2V to print from 35mm to 4x5 regularly. You will need different lenses of course, but most important you will need the appropriate lens mounts for each one. There are at least 3 mounting "cones" for the D2V. These are used for 35mm > 120, 120 > 4x5 and 4x5 alone. That is a rough breakdown.
I have converted my D2V to hold a Beseler color head. I still use the same 3 cones and lenses as well as the negative carriers.
All of my carriers are double notched to fit (and lock) between the platen and the condenser.