Your F100 with some top-tier ED glass should be fine. I have shot various 35mm rolls through my EOS system with pro-grade L-glass and with pro-grade film would put them against anything taken with a 645 any day of the week.
Glass, cellulose and composition are the three key ingredients in a good photograph. I have nailed damn near perfect shots on a $10 EOS 650 film body with my 70-200/4L IS. With that camera the only time I missed a shot was when I needed a wide and had a tele mounted, and vice-versa.
I shot an outside wedding reception with it today and was impressed. A little loud for my tastes but it gets the job done without complaint or issues. I have done 3 weddings in 35mm format + full-frame digital (more 35mm than digi, the digi is mainly to test exposure vs. older bodies and for my portfolio) using mostly Canon EOS systems and have never once had any issues. Prints and enlargements look great. I've ran the gamut on EOS bodies and I love the simplicity of the 650, and the AF of the later bodies like my Elan 7e.
Now I am on the other side of the fence here, I've been using 35mm and want to cross over into MF and I'm not afraid to manual focus. I ran a roll through my Nikkormat practicing focus time and I seem to nail it damn near every time. I was thinking the RB67 Pro-S for anything I would enlarge and anything planned or premeditated and my EOS system for when I need to get a quick shot or something I wouldn't need to enlarge past 4x6. thoughts?