It's a P.I.T.A., for sure. A tad easier on the digitals, as you don't have to memorize the function numbers, but a P.I.T.A. nonetheless. The only EOS cameras I'd suggest for mirror-up photography would be the EOS 1N-RS or the EOS RT. Both are incredibly cheap, and worth getting if you do that kind of shooting a lot. I'd get an RT for close ups, and use the 1V when you actually need autofocus and/or cannot afford the light loss of a pellicle mirror.
The bright side of the Nikon F's MLU is that you can always compare the MLU shot to the non-MLU shot!