Lots of fun and great work has been done in very "primitive" or "guessed at" exposure control situations. For example; Ansel's Moonrise, and with hand shuttered Petzvals, Brownies, Disposables...
One of the true joys of shooting negatives is the ability to ignore the camera and just shoot.
This is not to say that we can't or shouldn't try to manage the process/exposure, just that perfect exposure is in no way a guarantee of good photos.
IMO good content trumps perfect exposure every time.
Most times, alternate camera exposure settings simply mean alternate enlarger exposure settings for me.