I was there two years ago and although I had a tripod I just didn't take it out in the city. I shot MF Delta 400 with no problems. You can't go wrong, there is an image waiting where ever you go. I carried two Hasselblads one with a 50mm and one with a150mm a couple of filters and a light meter plus film for the day in a daypack and left the rest in our hotel room.
Buy a pass for the public transportation because the metro and buses are the easiest way plus walking to get around. Don't forget to eat .... the food is great. The people are friendly and in general easy to engage in conversation and ask directions if necessary.