My F2S predates me by twelve years! Hands down my favorite camera, but I recently aquired an F3HP at a price I couldn't refuse (free). As I put the F3 through its paces, it's interesting to note the evolutionary changes Nikon made. I suppose for hardworking pros in the '80s, the F3 probably made their lives easier overall.
But for me, the F2 remains my number one; really the only complaint I have is that I'm afraid of getting it wet (I don't use a flash, otherwise that might be another complaint). Besides that, it feels as though Nikon made it specifically for me. It fits my hands and my shooting style PERFECTLY. I almost always have the MD-1 attached, and my favorite focusing screen is the E.