Yes I use the photo secretary software with a Windows based system. It was designed for Windows 95 but run fine on Windows XP. There is only one problem when running on Windows XP that the setup program couldn't make the short cut on the start menu so you would have to do it yourself. Otherwise it's fine. I bought the Nikon cable but there were some third party cable available. I don't think either the software nor the cable is available any more. If you can find the cable then shoot me a message or email.