Good thoughts Fabrizio.
I have a buddy that used to shoot stock car racing on 4x5, don't remember what camera but it used a system something like grafmatic holders and was self cocking. As I remember, he said he could shoot off all six sheets in a 10-second pit stop.
Weegee and others did a fair amount of news reporting on 4x5 too.
My point is simply that photographic opportunities are typically made, not taken.
The old adage of f/8 and be there comes to mind. This fits with your thought on stock photography, content rules.
I'm not advocating a pure 4x5 approach, the operative gain you speak of is real.