I shoot mostly iso400 film, and good iso400 film at that. I'm not into crunchy 1970's grain/grit aesthetic so I use films like tmax400 and acros100. 6x6 MF is so much smoother and cleaner than 35mm. I also do a lot of LF, so I like smooth tones. If you don't enlarge past 8x10, perhaps 35mm is fine. I like slightly larger than that sometimes. If you're shooting live activities the 35mm versatility and speed might be good. If you're taking the time to use a tripod, etc. then MF is going to be a big step up in quality.