Printing from a larger negative is always a luxurious experience. In my opinion, if one is after really fine tonality, then it's got to be a no more than 3-4x enlargement, even if an 8-10x enlargement will barely show any grain from a Pan F+/Acros/TMX/etc. negative. I often enlarge my 35 mm negatives considerably, but even at 8x10" a full frame 6x6 image will print with considerably more delicacy, than 35 mm.
Whenever I can think a little before grabbing the shot, I reach for my TLR.
For me the real question is not MF or 35 mm, but LF or MF.
Shooting Delta 3200 in old medium format cameras with lenses that need to be stopped down well is great fun, BTW.