I shoot both 35mm and medium format. For me, the larger the format the slower I work. So this is one aspect. As for print quality, the pay off is when you print larger than 8x10. I made an 8x10 print from my 35mm neg of Ankor Wat in Cambodia. I have a tough time distinguishing the quality some shots I made with my 120 camera. I shot 35mm Fuji Acros souped in Xtol. My Canon F1 I feel the most comfortable with and I tend to shoot more film than my Zeiss Super Ikonta IV.