If that wasn't the case people would buy reproduction of famous paintings instead of original paintings. With modern techniques it is possible to have a PERFECT-looking reproduction of let's say a painting by Caravaggio, with all the paint relief, which is probably indistinguishable from the original at first, second and third sight. But the mind knows it's just a factory product.
There's a mystique in "hand-made" objects which sells. Digital workflow even when "laborious, time consuming and frustrating" IMO will never manage to acquire the same halo.
All this cannot be a substitute for the basic qualities of a print, its visual appeal etc. But it can be used as an added point of interest, and as an added point of value.