I'm terribly un-fit physically, so I'll need to adjust, take things slow, and use transportation (no hiking the Inka trail for me). I think I'll do fine at altitude - I've been at 10,000 feet here with no ill effects other than shortness of breath from the thin air, so going to Qusco should be ok. As far as subject matter, my interest is in urban landscape/architecture, street scenes, and portraits first and foremost. I'll be keeping it simple with just a Rolleiflex 2.8E, and shooting mostly color. I MIGHT add one of those new Lomo 6x12 cameras since they're relatively small and light for what they are and would enable me to get some wider/taller shots.