Depends what you are trying to do with it. When I shoot Delta 3200 it's for speed. If 1250 will do it I shoot Tri-X in Diafine. So I typically shoot 3200 at 3200. I develop in T-Max developer but might switch to DD-X when I run out. T-Max works well for it though. I develop per instructions for 6400 when shot at 3200 with results I really like.