Problems that I have had are fog on the gg and lens elements, and static. No lightning bolts, rather an affinity for every free particle to attach to various things including film and dark slides. Also dropping things in snow can be a royal pain.
All in all I have found it doable, if even more meticuloudly plodding than normal LF.
Here's my favorite acronym that I say to myself:
Focus- image focused and camera locked
Aperture- aperture set
Shutter- shutter closed
Tach- shutter speed set and cocked.
Only after my FAST check is complete do I pull the slide. This stupid little thing has saved me a lot of blown sheets.
Ask me later how to go out and shoot empty holders all day.