It all depends what you prefer. I have a 50-80-150-250 set with a couple of extension tubes. I use them all equally...when i want a 3 lens set, I leave the 250 at home simply because it is really heavy. If I went to a 2 lens set, I'd probably just get a 60 and a 120 Makro. Go ahead and shoot with the 80 and 150 and see what you feel like you are lacking. You might be surprised. If you feel the need to upgrade, get an Acute Matte screen. That makes a big difference!