Yes and you can calculate it by a simple arrangement of the view camera focusing formula. The greater the magnification, the less tolerance for negative to lens misalignment. If you want some real numbers, when enlarging a 4x5" negative to 11"x14", you have about one millimeter of negative DOF or about 2.5cm of baseboard/easel/paper DOF at f5.6. Of course there are subjective variables in the equation (like acceptable circle of confusion size which relates to print viewing distance). But as you can see, even if one wants to arguead nauseamabout print viewing distances and CoC sizes, the numbers I presented arenotin the micrometer order of magnitude and should be obtainable in just about any 4x5" enlarger out there.