I experimented with Dignan's divided developer several years ago and got terrible results with Konica and Kodak films (Portra 160NC was the worst) while Fuji films fared much better with the best results with Pro 160S. The 160NC images were extremely thin with a very yellow mask while the Pro160S was almost acceptable, but overall contrast was a bit low and cyan contrast low, and this was quite visible in prints with some subject matter.
So, yes, different films give different results. One could probably reformulate it to work better with the different films but it is a sure bet you will always have some crossover, so applications would have to be non-critical. One advantage is cost. Whereas the second bath should be used one-shot, the first bath can be re-used multiple times.