Every camera will have its own set of options, limitations, and ways of merging the two. Close up lenses (i.e. Rolleinar) can be fitted to just about anything, but the image qualiy may be a little less than using a prime lens with bellows focusing or extension tubes. For working very close with TLRs, you have parallax to contend with but dealing with it is not especially difficult, and doesn't require additional gadgets, though they do make life easier.
Then there is cost, both of the camera and the collection of accessories you'd aquire to make do what you want.

Only you can decide which trade-offs are important.