Quote Originally Posted by polyglot View Post
Hyperfocus is the optimum tradeoff between DOF and diffraction, assuming you know how much DOF you want.
I estimate the closest object and then check the hyperfocal distance to infinity (or furthest object) and set the focus at hyperfocal distance if infinity is wanted or focus about a third in if furhtest distance is less than infinity. I set the aperture according to the lens I'm using (or from the lens tables) but usually stop down one more stop for good measure.

That extra stop down might be overdoing it and getting me more into diffraction. What do you think?