Drum scan and colourimetrics + high end printer (not ink jet) will give you just devo prints from either tranny or negs, but negs are inherently sharper and will enlarge much easier with less USM required (unsharp masking). You must have a well-exposed tranny/neg before starting (critically with tranny film); anything like dark shadows or blown highlights will be picked up by the scanner and cannot be corrected: "blows" and "blocks" are literally final, so spot meter sensitive films (like RVP, RDP3 etc.). There is typically an 0.3 to 0.5 stop loss of light in the end print so images slightly over-exposed often scan the best, but it's quite a balancing act. .

Trannies illuminated on a lightbox are a tour de force and the best way to knock the sox off clients coming in for stickybeak, that's for sure. But don't discount at all how well that beauty translates into a finished print, on the right media under the right viewing conditions (e.g. framed, under spots). There is a lot of skill involved in scanning and carrying through the beauty to print stage and it cannot be rushed.