Profitable commerce requires a salable product.
Salable products are typically well defined and designed to suit an equally well defined market that is willing and able to buy the product.
So, the question you need to answer is "can you find and get access to a market that is willing and able to buy your prints at a profitable price?"
When you can answer yes, sure you can make money.
Until you find and get access to "that" market, no matter how good your work is, your "business" will struggle.