I can only print up to 10x8 and at that size I don't have any quality issues from 35mm and no one I've showed my photos to has commented negatively (apart from my awful composition, perhaps).

We have one crappy P&S digi and 10x8 prints from Superia 1600 look better than 6x4 prints from the digi. I've heard there's better digital, but then, there's also ULF film and I've heard oil paintings are grain free.