Not all substitute components were created equal. So, you have to do R&D to find out if they match what you are currently using. This takes money and trained staff. These are things that Kodak has been losing quite a bit of nowdays.
Therefore, I think that there will be the possibility for a decline in quality. Just MHO.
In just roll film or sheet too..?
Tmax 100 & 400 in 4x5 is about the best base material I have ever encountered, even if the smooth emulsion of 100 plays havoc on AN glass carriers...