Only if the scanner is miscalibrated (bad gamma settings and milky results are common) or the operator incompetent. I have no shortage of prints and scans from C41 where you cannot tell whether they're shot on film or digital. The colour accuracy is better on digital, but you basically need to be doing an A/B comparison against a Gretag-Macbeth to see the difference. Modern pro C41 films can be very accurate and you need to abuse them to get "different" results.
Originally Posted by tim elder
If you shoot a good DSLR, my personal opinion is that colour film is NOT worth it unless you shoot it in bigger than 35mm. So I shoot 6x7.