In my case, I don't have any option. The only room available is the bathroom - I've no 2nd bedroom or other convertible space.
And while the moisture issue is there, so is the exhaust fan which is specifically designed to exhaust moisture.
If the OP has flexible, re-purposable space elsewhere I'd say go to it. But if not, a good bathroom works well too.
12 x 16 is the largest size I print regularly, but I can and have done 16 x 20.