There is some loss, but not a lot. Modern enlarging lenses (other than the cheap ones) are very well corrected for color and
are capable of making outstanding color prints. Hand made prints will be somewhat sharper than the machine made scan to print items, particularly in the larger sizes. Scanning allows commercial print makers easier and more versatile controls. You may have some trouble duplicating this at the enlarger, although you can usually do it. The scans seem to be about 2800 dots per inch, which is pretty detailed and close to the resolution of most negatives, so the scanning prints are good. But hand made enlargements have a certain something extra.