I do E6 in a CPP2, but I've not tried it for cross-processing; there's a section in my FAQ that explains how I do it (including prewashes, etc), but it's not much more than following the (Fuji 5L kit) instructions with some recommendations gathered here from PE etc.
What's your reasoning for using E6 instead of C41 to do your massive push? Do you still want a negative, or are you aiming for a strangely coloured positive? Were you planning on using E6 CD as the only developer, followed by bleach+fix? I'm not sure what the activity level of E6 CD is nor what would be a good processing time for it as first dev since it's designed to run approximately to completion. Colours will be strange, what with it being CD3 instead of CD4.