Depends on the film selection. Sure, 4x5 is going to look noticeably better than anything from 35mm, but it's entirely possible to get a better image from 6x7 using a fine film than from 4x5 with a not-so-fine film.

For example and IMHO, 6x7 Acros looks better (in terms of detail, resolution, sharpness, etc) than 4x5 Fomapan 100, even in larger print sizes where you might expect the smaller negative to start suffering.

And none of it matters a damn in the face of content.