There is a very, very big difference between a print produced from 35mm and one produced from anything upwards of that, be it medium format or large format. The postage-stamp sized 35mm has definite limits to the amount of detail that can be recorded, and what can appear clear as the size is increased. True, excellent results are achievable up to poster size in negative film (but not really transparency), but it is still a tiny format with definite limits.

What irks me though is how people invest thousands in a large format kit but never print beyond 8x10 (I know of a few that only print postcard-sized prints!), when the format itself easily accommodates mural sized prints — the stuff to really make a statement in whatever genre you master. For all intents and purposes they may as well stick with 35mm.