Ionization of Neutral Compounds. Anthony Linden (alinden "at" oci.unizh.ch) suggests that if your compound is neutral and contains proton donor or acceptor groups, better crystals may grown by first protonating or deprotonating (as applicable) your compound. The ionic form of your compound could then take advantage of hydrogen bonding to yield better crystals. This will alter the electronic properties of your compound, but if a general confirmation of the success of a synthesis is what is needed from the structure determination, then this is not a problem.
Last edited by Mustafa Umut Sarac; 10-27-2013 at 03:27 AM. Click to view previous post history.