I pretty much always use the matrix meter on my F5- both for transparencies (I stick to velvia 100) and B&W negatives. It's almost always perfect- the problem with it in my opinion is that it's a very complicated matrix meter and I find it a little hard to predict when it is going to be wrong. I am always using my F5 to photograph action, so I count on the meter to deal with constant light changes, but if it starts giving readings that annoy me, I'll switch it off.

I don't use the F4 too much anymore, but I found the matrix meter both more fallible and more predictable when I did.