... The 250mm is relatively compact, and isn't that heavy. It's mostly empty space surrounded by metal. The 350mm starts to get ridiculous in terms of size and weight.
I agree about the weight of the 250mm and the 350mm. I do not find the 250mm cumbersome and I do not have a problem hand holding it for 1/500 second and 1/250 second. I would use a tripod if the shutter speed was 1/125 second or longer.
Warning!! Handling a Hasselblad can be harmful to your financial well being!
Nothing beats a great piece of glass!
I leave the digital work for the urologists and proctologists.