I have printed from scanned 4x5 negatives. Looks nice to my eye, but I expect a well done optical print would be nicer.
I think if I had the time and space, then I'd love to have a go at optical printing, but I lack both at the moment, and will do for the foreseeable future.
If you already have the darkroom, then I'd say you at least need to give it a try. Sure you could contact print, but I'm not sure I'd bother to use 4x5 at all to end up with a 4x5" print.