In general, I find that in my old age I am muddleheaded enough without contributing to it further by imbibing intoxicants, particularly before a photo session.

I suspect this question was asked with drugs like LSD, mescaline, psylocybin, or hallucinogenic mushrooms in mind. While these drugs do alter one's perspective, sometimes in a beneficial way, I still believe good photography is best done with a clear head.

Under the influence of mind altering drugs it is easy to spend ten minutes attaching the cable release and an hour pondering the mysteries of depth of field. Light meters provide information one doesn't quite know what to do with, and one is all too easily distracted by reflections in lens coatings, the spectacular engraving of f-stops, and the multicolored paisley diatoms that are crawling across the bellows.