I think that the loss of sharpness is directly proportional to how steady you're able to keep the camera regardless of what kind it is. I had no trouble keeping a Nikon FE with a 50 steady inside at f/1.4 at 1/60th of a second. It was decently bright, though, and I get into some problems when I got down any farther than that with an SLR. It's actually why I switched to rangefinders. I do, however, sometimes miss my FE...I took some nice photos with it.