Depends.

Much of my 35 mm work is closeup with flash illumination. I do nearly all of that hand-held. With flash, the only ill effect of motion (mine, subject's) is poor focus, and with mobile subjects that's an acceptable risk.

With long lenses, shooting hand-held is impossible.

Otherwise, it depends on the situation. When not shooting from tripod, I try to brace myself against something solid if that's possible.