jnanian>i know there are folks that swear by it, but it worked for me for 3 months, and stopped communicating with my scanner altogether.

Same here but...I finally read the instructions and it turned out Vuescan stopped working after I installed an extra part of Epson's software. After I trashed the "Epson Scanner Monitor" Vuescan saw the scanner. I'm on a Mac...don't know what you are running.