Your description of your desired results may be purely colorful exaggeration, or perhaps indicate that you have unrealistic expectations. 4x5 film and lensses only have so much resolution....

If you want the most resolution and sharpness possible of a distant cityscape, the first thing I would do, as already suggested, is take the photo on in sunshine after a hard rain. City air tends to be dusty and polluted, and the rain will increase transparency. The sunshine will cast shadows which will reveal details and increase the perception of sharpness. In general, higher contrast will increase the perception of sharpness.

As already suggested, some filtration will help with haze penetration. You might try several filters -- sometimes red is too much.

Tech-pan has very high resolution but can be tricky to get good pictorial results with. You might want to try TMax-100.

Near-optimum f-stop, camera stability and acccurate focusing matter. Is the plane of sharpest focus where you intended it to be? Check whether objects off the intended plane are sharper than objects on the plane.

Focusing on the hyperfocal distance might in fact be reduce the sharpness of the main subject. The concepts of depth-of-field and hyperfocal distance are based on the concept of acceptable deviations from perfect focus -- circles of confusion instead of perfect points. If you want the maximum resolution possible, your acceptable deviation from perfect sharpness might be much smaller than what is typically accepted. If so, focusing on half of the hyperfocal distance might leave infinity unacceptably blurry to you. My suggestion is to focus on the most important part of the subject and stop down to approx f16 to f22.

If you don't get as much depth-of-field as you want, you will either have to try tilts and swings (probably won't help much for this subject), or recompose, or decide to accept the lesser depth-of-field or stop down more and accept small amounts of diffraction smearing.

There are some similar aspects to the enlarging step: near optimum aperture from the lens, sufficiently flat film, aligned enlarger, etc. Knowing whether you have acheived the potential of the system is easier for this stage, because you can compare the prints to the film as viewed with a loupe. If the film has detail that isn't in the print, then the enlarging step needs attention.