If ou are talking true 'macro' work, meaning magnification ratios of 1:1 or larger then you will get the best results with a lens speciufically designed for that purpose. Process lenses will get you some of the way there as they are designed for close work but they are also designed for reproducing flat copy rather than dimensional objects. By the same token, any normnal plasmat or tessar lens in the 105 - 135 range that covers 4x5 will also give you acceptable performance in macro ranges. Note I say acceptable meaning that it should be fine for flowers and the like for fine art photography; I would not use it for product (like jewelry) or technical fine detail photography .... others may differ .