Hi Jim,
October is a great time to go, one thing though, if you plan of shooting waterfalls, there are none in October, they are usually dry (or close to dry) by then. But the fall color is beautiful if you hit it right. Most of the vistas you recognize are right off the road so they are readily accessible. I have some shots I made last year on my website
Most of those shots were within steps of the road.
Have fun on your trip. Let us know how it goes.