I had a problem with my 3200 in that Windows 2K decided to detect two instances of the scanner. I think problem occurred when I changed the cable to another USB port, but this was a while ago, so I can't be sure.
The Epson TWAIN driver absolutely refused to talk to the scanner, even after re-installing.
The fix that worked for me was to un-install the Epson Scan software, then use Control Panel->System->Hardware->Device Manager to un-install the devices under Universal Serial Bus Controllers, then reboot the machine. On starting (with all attached USB devices disconnected or turned off) , Windows will detect the USB controller and reinstall the USB motherboard devices (the drivers will already be on the system). This drastic action clears Windows memory of all the USB devices that have been attached to the computer. I then re-installed the scanner and software as per Epson's interactions and was back in business.
My system has a conventional (not USB) keyboard and mouse, so un-installing the USB devices caused no problems. However, your system may be different.
I have not experienced the problem since, but I haven't done anything to provoke it.
Try Windows Update. It may detect that you need an updated USB driver for your motherboard. Installing the new driver may fix the problem anyway. I believe Windows 2K USB support was also updated some time back.
Good luck and I hope this helps.